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Romac (Roxithromycin)
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Romac

Romac is an antibiotic that is used to treat infections such as infections of the chest, tonsils, skin or genitals. It works by killing or stopping the growth of bacteria (bugs). Like all antibiotics, Romac is not effective against infections caused by viruses.

Other names for this medication:
Aristomycin, Asmetic, Assoral, Azuril, Bazuctril, Biaxsig, Bicofen, Biostatik, Cadithro, Claramid, Crolix, Delos, Dorolid, Erybros, Floxid, Infectoroxit, Klomicina, Ladlid, Macrolid, Makrodex, Odonticina, Overal, Pedrox, Ramivan, Redotrin, Remora, Renicin, Rokilide, Rokithrid, Roksimin, Roksolit, Rolexit, Rolid, Romac, Romyk, Rossitrol, Rotramin, Roxacine, Roxithromycin, Roxithromycine, Roxithromycinum, Roxitromicina, Rulid

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Also known as: Roxithromycin

Description

Romac is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Romac is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the lactone ring. It is also currently undergoing clinical trials for the treatment of male-pattern hair loss.

Romac is available under several brandnames. Romac is not available in the United States. Romac is available in Australia, Israel and New Zealand. Romac has also been tested to possess antimalarial activity.

Romac prevents bacteria from growing, by interfering with their protein synthesis. Romac binds to the subunit 50S of the bacterial ribosome, and thus inhibits the synthesis of peptides. Romac has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila.

Dosage

Romac is typically prescribed for a period of 7 to 14 days and patients should take the medication for as long as it has been prescribed to prevent the infection from returning even if they become asymptomatic. Patients should not however, take doses larger than has been prescribed as this can result in an overdose. Overdosing requires immediate medical intervention and may present with symptoms which include abdominal pain, nausea, diarrhea, vomiting, and a general and prolonged feeling of illness.

Overdose

If you overdose Generic Romac and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Keep the tablets in the foil until it is time to take them.

Keep the tablets/in a cool dry place where the temperature stays below 30 degrees C.

Do not store Romac or any other medicine in the bathroom or near a sink.

Do not leave it in the car on hot days or on window sills.

Heat and dampness can destroy some medicines.

Keep it where children cannot reach it.

A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Side effects

The most common side effects associated with Romac are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

The safety of roxithromycin has not been demonstrated in patients with impaired hepatic or renal function. Caution should be exercised if roxithromycin is administered to patients with impaired hepatic or renal function. If administered to patients with severe impaired hepatic function (eg. hepatic cirrhosis with jaundice and/or ascites), consideration should be given to reducing the daily dosage to half the usual dosage.

Prolonged or repeated use of antibiotics including roxithromycin may result in superinfection by resistant organisms. In the event of superinfection, roxithromycin should be discontinued and appropriate therapy instituted.

When indicated, incision, drainage or other appropriate surgical procedures should be performed in conjunction with antibiotic therapy.

Antibiotic associated pseudomembranous colitis has been reported with many antibiotics. A toxin produced by Clostridium difficile appears to be the primary cause. The severity of the colitis may range from mild to life threatening. It is important to consider this diagnosis in patients who develop diarrhoea or colitis in association with antibiotic use (this may occur up to several weeks after cessation of antibiotic therapy). Mild cases usually respond to drug discontinuation alone. However, in moderate to severe cases, appropriate therapy with a suitable oral antibacterial agent effective against Clostridium difficile should be considered. Fluids, electrolytes and protein replacement therapy should be provided when indicated.

Roxithromycin, like erythromycin, has been shown in vitro to elicit a concentration - dependent lengthening in cardiac action potential duration. Such an effect is manifested only at supra – therapeutic concentrations. Accordingly, the recommended doses should not be exceeded. In certain conditions macrolides, including roxithromycin, have the potential to prolong the QT interval. Therefore roxithromycin should be used with caution in patients with congenital prolongation of the QT interval, with ongoing proarrhythmic conditions (ie uncorrected hypokalemia or hypomagnesaemia, clinically significant bradycardia), and in patients receiving Class IA and III antiarrhythmic agents.

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Misperceptions of harm among Natural American Spirit smokers: results from wave 1 of the Population Assessment of Tobacco and Health (PATH) study (2013-2014). With this added dimension of functional assessment, future application of the current spinal cord ischemia model have been greatly expanded. Accumulation of abnormal results in patients with poor metabolic control supports the importance of metabolic control in GSD type 1a. This growth inhibitory effect was variable among donors, reversible and heat-sensitive. There are no randomized trials comparing intra-arterial (IA) therapy with best medical treatment for acute ischemic stroke. Epithelioid sarcoma (ES) is a rare soft tissue neoplasm that usually arises in the distal extremities of young adults, presents a high rate of recurrences and metastases and frequently poses diagnostic dilemmas.

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Localization of cholecystokinin A and cholecystokinin B-gastrin receptors in the human stomach. Following irradiation scid mice receiving cultured human bone marrow cells by either i.v. There is a significantly high prevalence of alcohol abuse/dependence in this population. The main aim of our study was to assess the role of long-term leucine supplementation on molecular and metabolic response in skeletal muscle of trained rats after an exhaustion test. An overview of the study skill proficiency (or lack of it) of students with learning disabilities is provided, followed by the presentation of 15 student study skill strategies designed to assist students in their use of various study skills.

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The space between serratus anterior muscle and rib cage (Spatium intermusc. Primary responses of various auditory zone fields of the cortex of narcotized cats. Awareness of this late complication is necessary not only in patients after renal transplantation but also in patients after hematopoietic stem cell transplantation from matched unrelated donor. Red reflex examination in neonates: the need for early screening. This article discusses the current available data and identifies areas for further research. The effect of distal pancreatectomy on survival was studied by examination of the records of 174 patients who underwent splenectomy and total gastrectomy for gastric carcinoma. Interview and self-rated assessments of clinical and economic outcome were made pretreatment, at eight weeks and at 26 weeks after treatment. Further, policy reform at the community level becomes more feasible when need can be specified for a particular census tract. A presumptive diagnosis was made of disseminated nocardiosis of the spinal cord and lungs. Impact on exudate management, maintenance of a moist wound environment, and prevention of infection.

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Postoperative stress, assessed by a decrease in macrophage viability and an increase in cytotoxic cytokine production, is maximized after laparotomy compared with stress in murine hosts that underwent minimally invasive treatment. Extended operation for cancer of the splenic flexure and the descending colon. The model provides the theoretical basis for methods of determining regional blood flow, blood volume, and mean transit time from time-absorbance curves acquired from the images of tissue regions of interest (ROI) distal from the inlet site. The aim of this study was to assess the efficacy of this approach and the factors influencing the final outcome of treatment. The treatment of caustic agent-induced lesions of the primary segment of the digestive tract.

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The results were then grouped into intervals and compared to the different nosological entities of cerebral vascular pathology. This group was compared with the control group, formed of 24 patients who did not received HGFs. The clinical course of 27 women meeting the DSM-III-R criteria for bipolar disorder was followed during pregnancy and the postpartum period. A detailed example is provided for homogeneous bilayers composed of the monoanionic lipid phosphatidylglycerol. Quantitation of ethidium-stained closed circular DNA in agarose gels. The tasks of psychiatric nurses in long-term residential settings in The Netherlands. Pathology of the polyp revealed follicular lymphoma (FL) involving the lamina propria of the mucosa with extension into the submucosa. Since any association with temperature may be an artifact due to common, temperature-independent, annual rhythms in the parameters, these data were also analysed after removal of these circannual components by digital filtering. Immunoglobulin A subclass measurement in serum and saliva: sensitivity of detection of dimeric IgA2 in ELISA depends on the antibody used.

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Sleep Patterns and Dysfunctions in Children with Learning Problems. Antigenicity of hepatitis A virus after ultra-violet inactivation. The higher urinary iron values in normal male subjects can be explained in this way: a large iron supply from the transferrin to the thalassemic erythroid cells limits the contribution from this protein to the urinary iron indocin 25 mg generic . Statistical evaluations were performed using both chi-square and logistic regression analysis. Radiation therapy with small dose may be considered if the lesion is not amenable to surgical approach. The results were highly dependent on the culture temperature, the spread of hobo element being more efficient at 25 degrees C. On days 6-8, the intensity of nuclear staining was very low, and limited to the cells adjacent to the luminal epithelium. Suicide and attempted suicide occur in the context of terminal and severe medical illness. Nuclei from cultured human cells were examined by differential scanning calorimetry. Synthesis of the enzymes of the mandelate pathway by Pseudomonas putida.

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Clinical Significance of the Apparent Diffusion Coefficient Ratio in Prostate Cancer Treatment with Intensity-modulated Radiotherapy. (oat) arginine decarboxylase (ADC) gene under the control of a tetracycline-inducible promoter were generated. Epidemiological surveys of formaldehyde and nitrogen dioxide levels in indoor air. Cholinergic and GABAergic modulation of self-stimulation of lateral hypothalamus and ventral tegmentum: effects of carbachol, atropine, bicuculline, and picrotoxin. Pars Plana Vitrectomy for Vitreomacular Traction Syndrome: Analysing the Preoperative Prognostic Factors. A porcine model for the evaluation of virulence of Bordetella bronchiseptica. The structure of the testis and its duct system is reviewed with reference to the preparations in the Hunterian Anatomical Collection, Glasgow University, Scotland. Somatic mutations of the WAF1/CIP1 gene in primary prostate cancer. Homocysteine was significantly associated with the prevalence of NAFLD, particularly in female, obese or non-smoking adults. An application of the device to investigate the blood during its conservation (21 days at 4 degrees C) showed an absence of the SCL of whole blood.

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Human corneal keratocytes (5 x 10(4) cells/mL) were exposed to PHMB and chlorhexidine for the same time to determine the survival rate of keratocytes. Outcomes in a prospective observational cohort who underwent fetoscopic tracheal occlusion for severe fetal left diaphragmatic hernia without associated anomalies were compared with our historical nontreated cohort of matched fetuses of similar severity. While lesions appear suspicious on CT because of equidensity to cortex, MR imaging can establish the diagnosis by demonstrating same signal intensity of heterotopia and grey matter on T1- and T2-weighted as well as inversion-recovery sequences. Clinical immunology of inflammatory rheumatism and its consequences for therapy. Thus, detailed phenomics analysis is the key to functional genomics. Diagnostic, prognostic and therapeutic role of CD30 in lymphoma.

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Recent commercial suggestions that insect populations can be controlled through the use of ultrasound raises the question of whether or not certain insects have receptors that are sensitive to high-frequency sound. Embryonic exposure to model naphthenic acids delays growth and hatching in the pond snail Lymnaea stagnalis. We therefore used the cAMP-indicator dye FICRhR (refs 1, 2) to investigate the effect of several neuromodulators (octopamine, dopamine, acetylcholine, serotonin and proctolin) on cAMP distribution in identified neurons of the lobster stomatogastric ganglion (STG). Hyponatremia and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). In both the tibia and fibula the pattern of collagen orientation is characteristic, which may be related to the distribution of the bending forces normally operative in these bones. Complex partial status epilepticus (SE) has been reported rarely in children. This clinical study was conducted to compare the diagnostic yield of bitewing radiographs exposed with a conventional aluminum filter with matched bitewing radiographs exposed with a samarium/aluminum compound filter.

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