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Piodart (Pioglitazone)

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Piodart works by making cells more sensitive to insulin, which is used to regulate the level of glucose in the body. Improving insulin sensitivity (or reducing insulin resistance) makes it easier for sugar (glucose) in the blood to get into the cells.

Other names for this medication:
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Also known as: Pioglitazone


Piodart is an effective drug of the class thiazolidinedione (TZD) with hypoglycemic (antihyperglycemic, antidiabetic) action to treat diabetes mellitus type 2. Piodart contains the active ingredient Pioglitazone Hydrochloride. Pioglitazone helps to lower blood glucose levels by increasing the sensitivity of liver, fat, and muscle cells to insulin; enables cells to remove glucose from the blood more effectively, reduces the amount of glucose produced by the liver, and preserves the functioning of the cells in the pancreas that produce insulin. Piodart does not cause the body to make more insulin. Therefore, when used alone, it does not cause low blood glucose (hypoglycemia). Piodart is used either alone or in combination with other anti-diabetic medications (such as insulin, metformin, or a sulfonylurea such as glyburide). Piodart is not taken to treat type 1 diabetes.


The Piodart dosage your doctor prescribes will depend on several factors. These include:

  • the type and severity of the condition you’re using Piodart to treat
  • other medical conditions you may have, such as congestive heart failure (CHF)*
  • other medications that you’re taking to treat your type 2 diabetes
Typically, your doctor will start you on a low dosage. Then they’ll adjust it over time to reach the amount that’s right for you. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

* <em>Piodart</em> has a<em> boxed warning</em> for CHF. This is the most serious warning from the FDA. For more information, see “FDA warning: Congestive heart failure” at the beginning of this article.

Drug forms and strengths

Piodart comes as a tablet that you swallow, and you’ll usually take it once a day. Piodart is available in three strengths: 15 mg, 30 mg, and 45 mg.

Dosage for type 2 diabetes

Your doctor will likely have you start taking either a 15-mg or 30-mg dose of Piodart once a day. If needed, they may increase the dose by 15 mg for extra control of your blood sugar. The maximum dose of Piodart is 45 mg a day.

Your starting dose will depend on if you have other health conditions, such as CHF.* And the dose will be increased over time based on how your body responds.

And in some situations where your body may be very stressed, your doctor may need to change your dose or have you stop taking Piodart. So tell your doctor right away if you:

  • have a fever
  • have an infection
  • have had an accident
  • have just had or will have surgery
Never change your dosage of Piodart without first talking with your doctor. And before you start taking Piodart, be sure to tell them about any medical conditions you have or any other medications that you take. Your doctor will determine what the best dosage is for you.

* Piodart has a boxed warning for CHF. This is the most serious warning from the Food and Drug Administration (FDA). For more information, see “FDA warning: Congestive heart failure” at the beginning of this article.

What if I miss a dose?

If you miss your dose, wait and take Piodart when your next dose is due. Never take two doses in 1 day. If you have questions on when to take your next dose of Piodart after you’ve missed a dose, talk with your doctor or pharmacist.

To help make sure that you don’t miss a dose, try setting a reminder on your phone. A medication timer may be useful, too.

Will I need to use this drug long term?

Piodart is meant to be used as a long-term treatment. If you and your doctor determine that Piodart is safe and effective for you, you’ll likely take it long term.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. You may have signs of low blood sugar, such as extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Piodart are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment.

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Theoretical study of adsorption of O((3)P) and H(2)O on the rutile TiO(2)(110) surface. Here, we describe the use of centrifugal ultrafiltration for the separation of plasmid DNA isoforms based on differences in elongational flexibility of the supercoiled, open-circular, and linear plasmids. Decreased concentrations after 18 h of incubation were found for acetaldehyde, 3-methylbutanal, butyl acetate, acetonitrile, acrolein, methacrolein, 2-methylpropanal, 2-butanone, 2-methoxy-2-methylpropane, 2-ethoxy-2-methylpropane, and hexanal. Thus, the chromatic pupil light reflex can be used to monitor photoreceptor degeneration over a larger range of disease progression compared to standard electrophysiology. Pain was inconsistent and rare at presentation in contrast to the regularity of swelling or a painless mass. 2 Methylene-beta-alanine methyl ester: a toxic amino acid originating from the sponge Fasciospongia cavernosa.

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DNA and RNA were isolated from 54 esophageal adenocarcinoma samples and 89 non-small cell lung cancer samples and were analyzed for gene amplification, genotype at the polymorphism, gene expression, and association with overall survival. Forty-eight hours after the second acetaminophen dose, the activities of serum glutamic-pyruvic transaminase and alkaline phosphatase were increased compared with levels found in hamsters given only saline. The possibility of repeated hemorrhage as a delayed reaction to brain irradiation is emphasized. Adjusting for age, sex, and weight as covariates, we performed two-point and multipoint linkage analyses using the variance component linkage analysis method implemented in Sequential Oligogenic Linkage Analysis Routines. Cognitive impairment (CI) is a serious complication of multiple sclerosis (MS), and the domains affected are well established, but new affected domains such as theory of mind are still being identified. Ultrasonic assessment of subsequent unexplained infertility after ovulation induction. Although the long-term results showed tendency towards improvement, the difference was not significant. This case re-emphasized the importance of preventing dehydration and monitoring the blood coagulation fibrinolytic system during PE therapy in patients with how much does generic seroquel cost a suprasellar germ-cell tumor accompanied with diabetes insipidus.

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The human active breakpoint cluster region-related gene encodes a brain protein noroxin drug class with homology to guanine nucleotide exchange proteins and GTPase-activating proteins. Method for identifying and determining polycyclic aromatic hydrocarbons in foods, soil and drinking water. These data provide the first in vivo evidence that the CL is the primary source of progesterone throughout pregnancy in the bottlenose dolphin. Hormonal control of phenylalanine hydroxylase activity in isolated rat hepatocytes. High caries risk was related inversely to age, rank, education and years in service.

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Effects of maternal vitamin A status on kidney development: a pilot study. These results indicated that age-associated changes of bone marrow cell composition in rat are well correlated with the levels of cytokine related to bone marrow cell differentiation. Substantial quantities of MGF were secreted by several hybrids including the L23 line. Hypothesis of transition in two ways from atrial fibrillation to sinus rhythm. Nitrite production by stimulated human polymorphonuclear leukocytes supplemented with azide and catalase vasotec medication uses . Mutagens are shown to be present in a variety of commercially heat-processed foods.

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Nearly 15 years ago, female carriers of the fragile X mental retardation syndrome were noted to have an increased incidence of twin pregnancies. Development, characterization, and optimization of protein level in date bars using response surface methodology. Symmetric or asymmetric growth disturbances of the spine or thorax were established in 5-week-old rabbits. The seven members of the human 14-3-3 protein family regulate a diverse range of cell signaling pathways by formation of protein-protein complexes with signaling proteins that contain phosphorylated Ser/Thr residues within specific sequence motifs. These data demonstrate that extremely high doses of rsCD4 inactivate cell-free HIV-1 in vivo and suggest that high doses of rsCD4 may have some short-term therapeutic utility, such as with accidental or occupational HIV-1 exposure. Our techniques allow real-time combinatorial analysis of cell populations based on spatial location, gene expression, behavior and cell surface molecules within intact tumors.

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