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Piodart (Pioglitazone)
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Piodart

Piodart works by making cells more sensitive to insulin, which is used to regulate the level of glucose in the body. Improving insulin sensitivity (or reducing insulin resistance) makes it easier for sugar (glucose) in the blood to get into the cells.

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Also known as: Pioglitazone

Description

Piodart is an effective drug of the class thiazolidinedione (TZD) with hypoglycemic (antihyperglycemic, antidiabetic) action to treat diabetes mellitus type 2. Piodart contains the active ingredient Pioglitazone Hydrochloride. Pioglitazone helps to lower blood glucose levels by increasing the sensitivity of liver, fat, and muscle cells to insulin; enables cells to remove glucose from the blood more effectively, reduces the amount of glucose produced by the liver, and preserves the functioning of the cells in the pancreas that produce insulin. Piodart does not cause the body to make more insulin. Therefore, when used alone, it does not cause low blood glucose (hypoglycemia). Piodart is used either alone or in combination with other anti-diabetic medications (such as insulin, metformin, or a sulfonylurea such as glyburide). Piodart is not taken to treat type 1 diabetes.

Dosage

The Piodart dosage your doctor prescribes will depend on several factors. These include:

  • the type and severity of the condition you’re using Piodart to treat
  • other medical conditions you may have, such as congestive heart failure (CHF)*
  • other medications that you’re taking to treat your type 2 diabetes
Typically, your doctor will start you on a low dosage. Then they’ll adjust it over time to reach the amount that’s right for you. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

* <em>Piodart</em> has a<em> boxed warning</em> for CHF. This is the most serious warning from the FDA. For more information, see “FDA warning: Congestive heart failure” at the beginning of this article.

Drug forms and strengths

Piodart comes as a tablet that you swallow, and you’ll usually take it once a day. Piodart is available in three strengths: 15 mg, 30 mg, and 45 mg.

Dosage for type 2 diabetes

Your doctor will likely have you start taking either a 15-mg or 30-mg dose of Piodart once a day. If needed, they may increase the dose by 15 mg for extra control of your blood sugar. The maximum dose of Piodart is 45 mg a day.

Your starting dose will depend on if you have other health conditions, such as CHF.* And the dose will be increased over time based on how your body responds.

And in some situations where your body may be very stressed, your doctor may need to change your dose or have you stop taking Piodart. So tell your doctor right away if you:

  • have a fever
  • have an infection
  • have had an accident
  • have just had or will have surgery
Never change your dosage of Piodart without first talking with your doctor. And before you start taking Piodart, be sure to tell them about any medical conditions you have or any other medications that you take. Your doctor will determine what the best dosage is for you.

* Piodart has a boxed warning for CHF. This is the most serious warning from the Food and Drug Administration (FDA). For more information, see “FDA warning: Congestive heart failure” at the beginning of this article.

What if I miss a dose?

If you miss your dose, wait and take Piodart when your next dose is due. Never take two doses in 1 day. If you have questions on when to take your next dose of Piodart after you’ve missed a dose, talk with your doctor or pharmacist.

To help make sure that you don’t miss a dose, try setting a reminder on your phone. A medication timer may be useful, too.

Will I need to use this drug long term?

Piodart is meant to be used as a long-term treatment. If you and your doctor determine that Piodart is safe and effective for you, you’ll likely take it long term.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. You may have signs of low blood sugar, such as extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Piodart are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment.

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