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Pangraf (Tacrolimus)

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Pangraf is an immunosuppressant that lowers the activity of your immune system. You need a suppressed (lowered) immune system after receiving an organ transplant so your body doesn't reject the new organ.

Other names for this medication:
Acroli, Crolim, Cromus, Mustopic, Olmis, Pangraf, Protopic, Seegraf, Tacloran, Tacrel, Tacrim, Tacroderm, Tacrograf, Tacrokid, Tacrolimus, Tacromus, Tacrotor, Tacrovate, Tacroz, Tacstead, Talimus, Tarcel, Techlomus, Topgraf, Triplibact, Vingraf

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Also known as: Tacrolimus


Pangraf (tacrolimus) weakens your body's immune system, to help keep it from "rejecting" a transplanted organ such as a kidney. Organ rejection happens when the immune system treats the new organ as an invader and attacks it.

Pangraf is a prescription medicine and is used together with other medicines to prevent your body from rejecting a heart, liver, lung, or kidney transplant.

Pangraf is supplied as oral capsules, granules for oral suspension, and as an injection for intravenous use.

Pangraf capsules and oral granules are immediate-release medicines and they are not the same as tacrolimus extended-release tablets or tacrolimus extended-release capsules. Your healthcare provider should decide what medicine is right for you.


Generic Pangraf can be taken in form of capsules (0.5 mg, 1 mg, 5 mg) and in injectable form. The dosage of Generic Pangraf depends on the type of your disease and health state. Take Generic Pangraf 2 times a day. Take Generic Pangraf orally, once a day with or without food. Avoid grapefruit or grapefruit juice. Avoid vaccinations. Do not stop taking Generic Pangraf suddenly.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Pangraf are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Pangraf if you are allergic to tacrolimus or hydrogenated castor oil, or if you have used cyclosporine (Neoral, Sandimmune, Gengraf) within the past 24 hours.

Using Pangraf may increase your risk of developing serious infections or certain types of cancer, such as lymphoma or skin cancer. Your risk may be higher if you are treated over long periods of time with drugs that weaken the immune system. Ask your doctor about this risk and about symptoms to watch for.

Some people taking Pangraf after a kidney transplant have developed diabetes. This effect has been seen most commonly in people who are Hispanic or African-American.

To make sure Pangraf is safe for you, tell your doctor if you have::

problems with your liver, kidney, or heart that are not related to your transplant; long QT syndrome (in you or a family member); or if you are scheduled to receive a vaccine;

Tell your doctor if you plan to get pregnant. Tacrolimus may harm an unborn baby, and can worsen conditions such as diabetes or high blood pressure in the mother. Use effective birth control before and during treatment with Pangraf.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of tacrolimus on the baby.

If you are a man, use birth control before and during treatment with Pangraf if your sex partner is able to get pregnant.

Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

Ask a doctor if it is safe to breastfeed while using this medicine.

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